WISE is the opposite of:

"Keen" refers to being highly perceptive or intellectually sharp, which is closely related to being wise. Both terms suggest a level of awareness and understanding, making "keen" a synonym rather than an opposite of "wise."

"Smart" denotes being intelligent or quick-witted, which aligns closely with wisdom. Although "smart" may imply a certain level of cleverness, it does not represent a lack of understanding, thereby failing to serve as an antonym for "wise."

"Clever" indicates quick thinking and resourcefulness, sharing a positive connotation with wisdom. Like "smart," it does not convey the absence of insight or understanding, positioning it as a synonym rather than an opposite.

"Astute" describes someone who is shrewd and able to accurately assess situations, which is a quality associated with wisdom. This term complements "wise" rather than contradicts it, as both imply a degree of intelligence and perceptiveness.