Which of the following prescriptions requires a Medication Guide to be given to the patient?

Metoprolol is a beta-blocker used primarily for cardiovascular conditions. While it has specific safety information, it does not have the same level of concern regarding serious adverse effects that would mandate a Medication Guide. Thus, it is not required to provide this document to patients.

Amoxicillin is a commonly prescribed antibiotic. Although it carries some risks of allergic reactions and side effects, it does not require a Medication Guide. The potential complications associated with antibiotics are generally communicated through standard patient information rather than a formal Medication Guide.

Lisinopril is an ACE inhibitor used for hypertension and heart failure. While it does have important safety information, including the risk of angioedema and fetal toxicity, it does not fall under the category of medications that require a Medication Guide. The information is typically provided through regular patient counseling.