Which of the following medications may be crushed prior to administration?

Risedronate is a medication used to treat or prevent osteoporosis, and it belongs to a class of drugs known as bisphosphonates. Crushing or chewing risedronate tablets can interfere with its absorption in the body and may lead to gastrointestinal irritation. Therefore, it is recommended to take risedronate tablets whole with a full glass of water on an empty stomach.

Bupropion XL is an extended-release medication commonly prescribed for depression and smoking cessation. Crushing or breaking the extended-release tablets can disrupt the intended slow release of the medication into the bloodstream, potentially causing an overdose or adverse effects. It is crucial to swallow bupropion XL tablets whole to maintain proper drug delivery.

Diltiazem ER stands for extended-release formulations of the medication diltiazem, which is used to treat high blood pressure and chest pain. Crushing or breaking these extended-release tablets can alter the drug's release mechanism, leading to potentially dangerous fluctuations in blood levels. It is essential to take diltiazem ER tablets whole to ensure controlled and sustained drug release.