Which of the following medications may be crushed prior to administration?

Risedronate is a bisphosphonate used to treat osteoporosis and has an enteric coating that protects it from gastric acid, as well as a specific release profile that must be maintained. Crushing this medication would alter its absorption and effectiveness, making it unsuitable for this method of administration.

Bupropion XL is an extended-release formulation of the antidepressant bupropion. Crushing this tablet would disrupt its extended-release mechanism, leading to a rapid release of the drug, which could increase the risk of side effects and toxicity. Therefore, it should not be crushed.

Diltiazem ER is an extended-release medication used for hypertension and angina. Similar to bupropion XL, crushing diltiazem ER would compromise its extended-release properties, resulting in a potential overdose and increased side effects due to the rapid release of the active ingredient into the bloodstream.