Which of the following medications is contraindicated with nitroglycerin?

Rationale

Sildenafil is contraindicated with nitroglycerin.

Sildenafil, a phosphodiesterase-5 inhibitor, can cause significant hypotension when taken with nitroglycerin, which is a vasodilator. The combination can lead to dangerously low blood pressure, making this interaction critical for patient safety.

A (Amoxicillin) YOUR ANSWER

Amoxicillin is an antibiotic used to treat bacterial infections and does not have a known interaction with nitroglycerin. It does not affect blood pressure or vascular tone, making it safe to use concurrently with nitroglycerin without any contraindications.

B (Sildenafil) CORRECT

Sildenafil's mechanism of action involves vasodilation, which, when combined with nitroglycerin, can lead to severe hypotension. This dangerous interaction arises because both medications lower blood pressure, and their combined effects can amplify the risk of cardiovascular complications. Therefore, sildenafil is specifically contraindicated in patients taking nitroglycerin.

C (Levothyroxine) YOUR ANSWER

Levothyroxine is a thyroid hormone replacement that does not interact with nitroglycerin. It primarily affects metabolic processes and does not have any direct influence on blood pressure or cardiovascular function, allowing it to be taken safely alongside nitroglycerin.

D (Metformin) YOUR ANSWER

Metformin is an antidiabetic medication used to manage blood glucose levels in Type 2 diabetes. It does not affect blood pressure and does not have contraindications when used with nitroglycerin, making it safe for concurrent use.

Conclusion

In summary, sildenafil is the only medication among the choices that poses a significant risk when used with nitroglycerin due to the potential for severe hypotension. The other options—amoxicillin, levothyroxine, and metformin—do not present such risks and can be safely administered with nitroglycerin. Understanding these interactions is critical for ensuring patient safety in pharmacotherapy.

Which of the following medications is contraindicated with nitroglycerin?

Sildenafil is contraindicated with nitroglycerin.

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