The immune system is a network of cells, tissues, and organs that defends the body against attacks by foreign invaders. These invaders are primarily microbes—tiny organisms such as bacteria, parasites, and fungi—that can cause infections. Viruses also cause infections, but are too primitive to be classified as living organisms. The human body provides an ideal environment for many microbes. It is the immune system's job to keep the microbes out or destroy them. The immune system is amazingly complex. It can recognize and remember millions of different enemies, and it can secrete fluids and cells to wipe out nearly all of them. The secret to its success is an elaborate and dynamic communications network. Millions of cells, organized into sets and subsets, gather and transfer information in response to an infection. Once immune cells receive the alarm, they produce powerful chemicals that help to regulate their own growth and behavior, enlist other immune cells, and direct the new recruits to trouble spots. Although scientists have learned much about the immune system, they continue to puzzle over how the body destroys invading microbes, infected cells, and tumors without harming healthy tissues. New technologies for identifying individual immune cells are now allowing scientists to determine quickly which targets are triggering an immune response. Improvements in microscopy are permitting the first-ever observations of living B cells, T cells, and other cells as they interact within lymph nodes and other body tissues. In addition, scientists are rapidly unraveling the genetic blueprints that direct the human immune response, as well as those that dictate the biology of bacteria, viruses, and parasites. The combination of new technology with expanded genetic information will no doubt reveal even more about how the body protects itself from disease.