Therapeutic duplication may be a concern for a patient prescribed both trazodone and:

Rationale

Therapeutic duplication may be a concern for a patient prescribed both trazodone and nortriptyline.

Trazodone and nortriptyline are both antidepressants that belong to the class of serotonin reuptake inhibitors and tricyclic antidepressants, respectively. When prescribed together, they can lead to overlapping therapeutic effects, increasing the risk of side effects and potential toxicity.

A (nabumetone.) YOUR ANSWER

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief and inflammation control. It does not share the same pharmacological class or therapeutic effects as trazodone, and therefore does not present a significant risk of therapeutic duplication when used concurrently.

B (nystatin.) YOUR ANSWER

Nystatin is an antifungal medication primarily used to treat fungal infections. It operates through a different mechanism than trazodone and does not have overlapping therapeutic effects, thus making therapeutic duplication unlikely when these two medications are prescribed together.

C (nortriptyline.) CORRECT

Both trazodone and nortriptyline are antidepressants that affect serotonin levels in the brain, which can lead to an increased risk of side effects such as sedation and serotonin syndrome. The use of both medications simultaneously is considered therapeutic duplication, as they could amplify each other’s effects and risks.

D (nicardipine.) YOUR ANSWER

Nicardipine is a calcium channel blocker used to treat high blood pressure and angina. It does not overlap pharmacologically with trazodone, and therefore does not present a concern for therapeutic duplication when prescribed alongside trazodone.

Conclusion

Therapeutic duplication occurs when two medications with similar therapeutic effects are prescribed together, potentially leading to increased side effects and toxicity. In this case, trazodone and nortriptyline both act as antidepressants, making their concurrent use a concern for therapeutic duplication. The other options—nabumetone, nystatin, and nicardipine—do not have overlapping mechanisms or therapeutic purposes, thus posing no such risk when combined with trazodone.

Therapeutic duplication may be a concern for a patient prescribed both trazodone and:

Therapeutic duplication may be a concern for a patient prescribed both trazodone and nortriptyline.

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