First group of digits in NDC identifies the:

The license holder refers to the entity authorized to distribute the drug but is not necessarily the manufacturer itself. While the license holder may overlap with the manufacturer, the NDC specifically identifies the manufacturer rather than the broader category of license holders who may sell or distribute the product.

Package size indicates the quantity or volume of the drug contained in a package but is represented in the last segment of the NDC. This information is vital for understanding dosing and usage but does not relate to the identification of the manufacturer, which is captured in the first segment.

The product refers to the specific medication or formulation and is identified in the second segment of the NDC, not the first. The distinction between the manufacturer and the product is essential for regulation and tracking, as different products can be manufactured by the same company.