According to the Institute for Safe Medication Practices (ISMP), which of the following is classified as a high-alert medication?

Rationale

Methotrexate (Rheumatrex)

According to the :contentReference[oaicite:0]{index=0}, high-alert medications are drugs that have a higher risk of causing significant patient harm when used in error. Methotrexate is classified as a high-alert medication due to the risk of severe toxicity, especially when dosing errors occur (e.g., daily vs. weekly dosing).

A (Methotrexate (Rheumatrex)) CORRECT

Correct. Methotrexate is a high-alert medication because incorrect dosing can lead to serious adverse effects, including bone marrow suppression and organ toxicity.

B (Methylprednisolone (Medrol)) YOUR ANSWER

Incorrect. Methylprednisolone is a corticosteroid and is not classified as a high-alert medication by ISMP.

C (Meloxicam (Mobic)) YOUR ANSWER

Incorrect. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) and is not on the ISMP high-alert list.

D (Methimazole (Tapazole)) YOUR ANSWER

Incorrect. Methimazole is used to treat hyperthyroidism and is not considered a high-alert medication by ISMP.

Conclusion

Methotrexate is classified as a high-alert medication due to its potential for serious harm if used incorrectly, making Choice A the correct answer.

According to the Institute for Safe Medication Practices (ISMP), which of the following is classified as a high-alert medication?

Methotrexate (Rheumatrex)

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