A pharmacy must utilize a DEA Form 222 or CSOS to order:

Rationale

Hydromorphone

A pharmacy must use a **DEA Form 222** or the **Controlled Substance Ordering System (CSOS)** to order **Schedule II controlled substances**. Hydromorphone is a Schedule II opioid with a high potential for abuse and strict regulatory controls, so its purchase requires these specific DEA-approved ordering methods.

A (guaifenesin/codeine.) YOUR ANSWER

This is incorrect. Guaifenesin/codeine preparations are typically Schedule V, which have lower abuse potential and do **not** require DEA Form 222 or CSOS for ordering.

B (acetaminophen/codeine.) YOUR ANSWER

This is incorrect. Depending on the codeine content, this combination is usually Schedule III. Schedule III drugs do not require DEA Form 222 or CSOS.

C (naloxone.) YOUR ANSWER

This is incorrect. Naloxone is **not a controlled substance**, so it can be ordered without DEA Form 222 or CSOS.

D (hydromorphone.) CORRECT

This is correct. As a Schedule II controlled substance, hydromorphone requires DEA Form 222 or CSOS for legal ordering and documentation.

Conclusion

Ordering Schedule II medications requires strict DEA compliance. Hydromorphone is the only option listed that falls into this category, making it necessary to use DEA Form 222 or CSOS for its purchase and ensuring controlled substance regulations are followed.

A pharmacy must utilize a DEA Form 222 or CSOS to order:

Hydromorphone

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