A pharmacy must utilize a DEA Form 222 or CSOS to order:

Rationale

Hydromorphone

A DEA Form 222 or Controlled Substance Ordering System (CSOS) is required to order **Schedule II controlled substances**. Hydromorphone is a Schedule II opioid, meaning it has a high potential for abuse and strict regulatory controls. Therefore, pharmacies must use DEA Form 222 or CSOS to order it.

A (Guaifenesin/codeine) YOUR ANSWER

This is incorrect. This combination is typically classified as a Schedule V controlled substance due to its low codeine content. Schedule V medications do not require DEA Form 222 for ordering.

B (Acetaminophen/codeine) YOUR ANSWER

This is incorrect. This combination is usually classified as Schedule III (depending on codeine content). Schedule III medications can be ordered without DEA Form 222.

C (Naloxone) YOUR ANSWER

This is incorrect. Naloxone is not a controlled substance and is used to reverse opioid overdoses. Therefore, it does not require DEA Form 222 or CSOS.

D (Hydromorphone) CORRECT

This is correct. Hydromorphone is a Schedule II controlled substance, and all Schedule II drugs require DEA Form 222 or CSOS for ordering.

Conclusion

DEA Form 222 and CSOS are specifically required for ordering Schedule II controlled substances. Among the options, hydromorphone is the only Schedule II medication, making it the correct answer.

A pharmacy must utilize a DEA Form 222 or CSOS to order:

Hydromorphone

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